| 8 | Tore-Andre Flo | Quarter-finals | UEFA Champions League 99/00 |
| 7 | Nicolas Anelka | Group Stage | UEFA Champions League 10/11 |
| 6 | Olivier Giroud | Group Stage | UEFA Champions League 20/21 |
| 6 | Didier Drogba | Group Stage | UEFA Champions League 11/12 |
| 6 | Didier Drogba | Group Stage | UEFA Champions League 07/08 |
| 6 | Didier Drogba | Group Stage | UEFA Champions League 06/07 |
| 5 | Willian | Group Stage | UEFA Champions League 15/16 |
| 5 | Oscar | Group Stage | UEFA Champions League 12/13 |
| 5 | Didier Drogba | Group Stage | UEFA Champions League 08/09 |
| 5 | Didier Drogba | Group Stage | UEFA Champions League 04/05 |
| 4 | Timo Werner | Group Stage | UEFA Champions League 21/22 |
| 4 | Timo Werner | Group Stage | UEFA Champions League 20/21 |
| 4 | Fernando Torres | Group Stage | UEFA Champions League 13/14 |
| 4 | Frank Lampard | Round of 16 | UEFA Champions League 07/08 |
| 4 | Frank Lampard | Round of 16 | UEFA Champions League 04/05 |
| 4 | John Terry | Group Stage | UEFA Champions League 04/05 |
| 4 | Frank Lampard | Group Stage | UEFA Champions League 03/04 |
| 4 | Dennis Wise | Second Group Stage | UEFA Champions League 99/00 |
| 3 | Raheem Sterling | Group Stage | UEFA Champions League 22/23 |
| 3 | Kai Havertz | Group Stage | UEFA Champions League 21/22 |
| 3 | Tammy Abraham | Group Stage | UEFA Champions League 19/20 |
| 3 | Willian | Group Stage | UEFA Champions League 17/18 |
| 3 | Michy Batshuayi | Group Stage | UEFA Champions League 17/18 |
| 3 | Eden Hazard | Group Stage | UEFA Champions League 17/18 |
| 3 | Eden Hazard | Group Stage | UEFA Champions League 14/15 |
| 3 | Samuel Eto'o | Group Stage | UEFA Champions League 13/14 |
| 3 | Demba Ba | Group Stage | UEFA Champions League 13/14 |
| 3 | Fernando Torres | Group Stage | UEFA Champions League 12/13 |
| 3 | Juan Mata | Group Stage | UEFA Champions League 12/13 |
| 3 | Frank Lampard | Group Stage | UEFA Champions League 11/12 |
| 3 | Ramires | Group Stage | UEFA Champions League 11/12 |
| 3 | Fernando Torres | Group Stage | UEFA Champions League 11/12 |
| 3 | Salomon Kalou | Group Stage | UEFA Champions League 09/10 |
| 3 | Didier Drogba | Group Stage | UEFA Champions League 09/10 |
| 3 | Nicolas Anelka | Group Stage | UEFA Champions League 09/10 |
| 3 | Frank Lampard | Group Stage | UEFA Champions League 08/09 |
| 3 | Andriy Shevchenko | Group Stage | UEFA Champions League 06/07 |
| 3 | Gianfranco Zola | Quarter-finals | UEFA Champions League 99/00 |
| 2 | Kai Havertz | Group Stage | UEFA Champions League 22/23 |
| 2 | Pierre-Emerick Aubameyang | Group Stage | UEFA Champions League 22/23 |
| 2 | Romelu Lukaku | Group Stage | UEFA Champions League 21/22 |
| 2 | Christian Pulisic | Round of 16 | UEFA Champions League 21/22 |
| 2 | Jorginho | Group Stage | UEFA Champions League 21/22 |
| 2 | Christian Pulisic | Group Stage | UEFA Champions League 20/21 |
| 2 | Callum Hudson-Odoi | Group Stage | UEFA Champions League 20/21 |
| 2 | Hakim Ziyech | Group Stage | UEFA Champions League 20/21 |
| 2 | Mason Mount | Quarter-finals | UEFA Champions League 20/21 |
| 2 | Cesar Azpilicueta | Group Stage | UEFA Champions League 19/20 |
| 2 | Jorginho | Group Stage | UEFA Champions League 19/20 |
| 2 | Oscar | Group Stage | UEFA Champions League 15/16 |
| 2 | Diego Costa | Group Stage | UEFA Champions League 15/16 |
| 2 | Didier Drogba | Group Stage | UEFA Champions League 14/15 |
| 2 | Francesc Fabregas | Group Stage | UEFA Champions League 14/15 |
| 2 | Nemanja Matic | Group Stage | UEFA Champions League 14/15 |
| 2 | John Terry | Group Stage | UEFA Champions League 14/15 |
| 2 | Eden Hazard | Group Stage | UEFA Champions League 13/14 |
| 2 | Ramires | Group Stage | UEFA Champions League 13/14 |
| 2 | David Luiz | Group Stage | UEFA Champions League 12/13 |
| 2 | Raul Meireles | Group Stage | UEFA Champions League 11/12 |
| 2 | Branislav Ivanovic | Group Stage | UEFA Champions League 11/12 |
