| Players | Total | Start | Sub | CO | Off | Goals |
|---|---|---|---|---|---|---|
 Piotr Zielinski | 36 | 33 | 4 | 3 | 10 | 6 |
Kalidou Koulibaly | 35 | 35 | - | - | 1 | 2 |
Arkadiusz Milik | 35 | 27 | 11 | 8 | 10 | 17 |
Dries Mertens | 35 | 23 | 14 | 12 | 10 | 16 |
Jose Callejon | 34 | 29 | 9 | 5 | 7 | 3 |
Allan | 33 | 28 | 5 | 5 | 2 | 1 |
Lorenzo Insigne | 28 | 24 | 5 | 4 | 10 | 10 |
Elseid Hysaj | 27 | 24 | 14 | 3 | 5 | - |
Fabian | 27 | 20 | 15 | 7 | 4 | 5 |
Kevin Malcuit | 24 | 20 | 18 | 4 | 5 | - |
Simone Verdi | 22 | 9 | 21 | 13 | 9 | 3 |
Raul Albiol | 20 | 19 | 7 | 1 | - | 1 |
Mario Rui | 20 | 17 | 16 | 3 | 4 | 1 |
Adam Ounas | 18 | 6 | 23 | 12 | 6 | 3 |
David Ospina | 17 | 16 | 17 | 1 | 1 | - |
Nikola Maksimovic | 17 | 15 | 18 | 2 | 2 | - |
Faouzi Ghoulam | 16 | 12 | 15 | 4 | 3 | 1 |
Alex Meret | 14 | 13 | 12 | 1 | - | - |
Marek Hamsik | 13 | 12 | 7 | 1 | 7 | - |
Amadou Diawara | 13 | 8 | 19 | 5 | 5 | - |
Sebastiano Luperto | 12 | 6 | 28 | 6 | 1 | - |
Amin Younes | 12 | 6 | 11 | 6 | 6 | 3 |
Orestis Karnezis | 9 | 9 | 29 | - | - | - |
Marko Rog | 9 | 4 | 15 | 5 | 3 | 1 |
Vlad Chiriches | 3 | 3 | 8 | - | 2 | - |
Gianluca Gaetano | 2 | - | 8 | 2 | - | - |
Antonio Pio Daniele | - | - | 1 | - | - | - |
Davide Marfella | - | - | 2 | - | - | - |
Alessandro D'Andrea | - | - | 13 | - | - | - |
Nikita Contini | - | - | 1 | - | - | - | 531 | 418 | 366 | 113 | 113 | 73 |
Total = Total appearances,
Start = Total started,
CO = Came on,
Sub = Started as a sub,
Off = Taken off .