| # | Players | Clubs | Nationality | GC | More |
|---|---|---|---|---|---|
| 1 | Diego Lopez | Espanyol | Spain | 48 | |
| 2 | Pau Lopez | Real Betis | Spain | 48 | |
| 3 | Sergio Asenjo | Villarreal | Spain | 47 | |
| 4 | Fernando Pacheco | CD Alaves | Spain | 46 | |
| 5 | Jordi Masip | Real Valladolid | Spain | 46 | |
| 6 | Tomas Vaclik | Sevilla | Czech Republic | 44 | |
| 7 | Oier Olazabal | Levante | Spain | 42 | |
| 8 | Ruben Blanco | Celta Vigo | Spain | 40 | |
| 9 | Thibaut Courtois | Real Madrid | Belgium | 39 | |
| 10 | Ivan Cuellar | CD Leganes | Spain | 38 | |
| 11 | Geronimo Rulli | Real Sociedad | Argentina | 36 | |
| 12 | Iago Herrerin | Athletic Bilbao | Spain | 36 | |
| 13 | Stole Dimitrievski | Rayo Vallecano | North Macedonia | 36 | |
| 14 | David Soria | Getafe | Spain | 35 | |
| 15 | Neto | Valencia | Brazil | 35 | |
| 16 | Alberto Garcia | Rayo Vallecano | Spain | 35 | |
| 17 | Marc-Andre ter Stegen | Barcelona | Germany | 34 | |
| 18 | Roberto Santamaria | Huesca SD | Spain | 31 | |
| 19 | Marko Dmitrovic | Eibar | Serbia | 30 | |
| 20 | Jan Oblak | Atletico Madrid | Slovenia | 30 |
GC = Goals conceded