| Group D | P | W | D | L | GF | GA | GD | points |
|---|---|---|---|---|---|---|---|---|
 Villarreal | 6 | 2 | 4 | 0 | 3 | 1 | 2 | 10 |
 Benfica | 6 | 2 | 2 | 2 | 5 | 5 | 0 | 8 |
 Manchester United | 6 | 1 | 3 | 2 | 3 | 4 | -1 | 6 |
 Lille OSC | 6 | 1 | 3 | 2 | 1 | 2 | -1 | 6 |
Wednesday 7 December 2005 | |||||||
| Villarreal | 1 | - | 0 | Lille OSC | 19:45 | STATS» | |
| Benfica | 2 | - | 1 | Manchester United | 19:45 | STATS» | |
Tuesday 22 November 2005 | |||||||
| Lille OSC | 0 | - | 0 | Benfica | 19:45 | STATS» | |
| Manchester United | 0 | - | 0 | Villarreal | 19:45 | STATS» | |
Wednesday 2 November 2005 | |||||||
| Lille OSC | 1 | - | 0 | Manchester United | 19:45 | STATS» | |
| Benfica | 0 | - | 1 | Villarreal | 19:45 | STATS» | |
Tuesday 18 October 2005 | |||||||
| Villarreal | 1 | - | 1 | Benfica | 19:45 | STATS» | |
| Manchester United | 0 | - | 0 | Lille OSC | 19:45 | STATS» | |
Tuesday 27 September 2005 | |||||||
| Lille OSC | 0 | - | 0 | Villarreal | 19:45 | STATS» | |
| Manchester United | 2 | - | 1 | Benfica | 19:45 | STATS» | |
Wednesday 14 September 2005 | |||||||
| Villarreal | 0 | - | 0 | Manchester United | 19:45 | STATS» | |
| Benfica | 1 | - | 0 | Lille OSC | 19:45 | STATS» | |