| Group E | P | W | D | L | GF | GA | GD | points |
|---|---|---|---|---|---|---|---|---|
 AC Milan | 6 | 3 | 2 | 1 | 12 | 6 | 6 | 11 |
 PSV Eindhoven | 6 | 3 | 1 | 2 | 4 | 6 | -2 | 10 |
 FC Schalke 04 | 6 | 2 | 2 | 2 | 12 | 9 | 3 | 8 |
 Fenerbahce | 6 | 1 | 1 | 4 | 7 | 14 | -7 | 4 |
Tuesday 6 December 2005 | |||||||
| AC Milan | 3 | - | 2 | FC Schalke 04 | 19:45 | STATS» | |
| PSV Eindhoven | 2 | - | 0 | Fenerbahce | 19:45 | STATS» | |
Wednesday 23 November 2005 | |||||||
| FC Schalke 04 | 3 | - | 0 | PSV Eindhoven | 19:45 | STATS» | |
| Fenerbahce | 0 | - | 4 | AC Milan | 19:45 | STATS» | |
Tuesday 1 November 2005 | |||||||
| FC Schalke 04 | 2 | - | 0 | Fenerbahce | 19:45 | STATS» | |
| PSV Eindhoven | 1 | - | 0 | AC Milan | 19:45 | STATS» | |
Wednesday 19 October 2005 | |||||||
| Fenerbahce | 3 | - | 3 | FC Schalke 04 | 19:45 | STATS» | |
| AC Milan | 0 | - | 0 | PSV Eindhoven | 19:45 | STATS» | |
Wednesday 28 September 2005 | |||||||
| Fenerbahce | 3 | - | 0 | PSV Eindhoven | 19:45 | STATS» | |
| FC Schalke 04 | 2 | - | 2 | AC Milan | 19:45 | STATS» | |
Tuesday 13 September 2005 | |||||||
| PSV Eindhoven | 1 | - | 0 | FC Schalke 04 | 19:45 | STATS» | |
| AC Milan | 3 | - | 1 | Fenerbahce | 19:45 | STATS» | |